AET Symposium: Channel Surfing: Impact on Treatment Strategies
This symposium will address the role of ion channels in the pathophysiology of epilepsy and its treatment. There will be a review of the role of voltage- and receptor-gated ion channels in controlling membrane excitability. The genetic assessment of patients suspected of having channel disorders will be outlined. The importance of ion channels as targets for treatment with antiepileptic medications (AEDs) will be defined. Among topics to be discussed are the impact of developmental differences in chloride transporters on treatment of seizures in children; the contribution of GABAA receptor availability during periods of intense neuronal excitability to the development of intractable status epilepticus; benign neonatal familial convulsions (BNFC) as an example of a genetic epilepsy due to deficits in Kv7.2 and Kv7.3 channels. Medical management of epilepsy is enhanced by knowledge of the specific mechanisms of action of AEDs on ion channels, leading to more rational therapy and improved clinical outcomes.
• Apply an understanding of the role of ion channels in managing patients with epilepsy
• Recognize epilepsy syndromes due to genetic abnormalities in ion channels
• Apply knowledge of ion channel pathophysiology in selecting AEDs and in assessing the role of newly developed drugs.
Intermediate (see page 101 for details)
Co-Chairs: L. James Willmore, M.D. and H. Steve White, Ph.D.
Introduction and Overview
L. James Willmore, M.D.
Central Nervous System Channels: Review of the Basics
Michael A. Rogawski, M.D., Ph.D.
Role of the Sodium Channel in Clinical Disorders: Challenges for Rational Treatment
Samuel F. Berkovic, M.D.
GABA-Induced Depolarization: A Tale of Opposing Forces
Jong M. Rho, M.D.
Potassium Channelopathies: Consequences and Impact on Treatment
Karen S. Wilcox, Ph.D.