Plenary II: Neurostimulation in the Treatment of Epilepsy: The Road Traveled and the Road Ahead
Program Length: 90 minutes
Despite the introduction of a large number of new AEDs in recent years, the number of patients with seizures who are refractory to medical therapy has not been significantly reduced. This has prompted renewed interest in studies of therapy with neurostimulation. Neurostimulation for the treatment of epilepsy has the benefits of no drug-related side effects and mechanisms of action presumed to be distinct from antiepileptic drugs, although the actual mechanisms of action are not established. Following the approval in 1997 of vagus nerve stimulation for adjunctive treatment of partial seizures, more recent trials have targeted intracranial sites. Just recently, separate pivotal trials for both programmed anterior thalamic stimulation and responsive neurostimulation have been completed in patients with intractable partial seizures. This symposium will focus on the principles of neurostimulation, the different types of therapy, the results of the clinical trials, and the questions that remain for the optimal application of these novel therapies.
• Apply the principles and targets of the various types of neurostimulation (chronic programmed and responsive) in determining which of these potential therapies might be appropriately used for the treatment of epilepsy
• Utilize the results of clinical trials for the three neurostimulation treatment modalities that have either been approved or have completed pivotal trials incorporating these treatment modalities into the treatment of selected patients with pharmacoresistent epilepsy
• Address unresolved questions regarding the application of neurostimulation as therapy for epilepsy and learn about additional investigations when developing care plans for patients with intractable epilepsy.
Intermediate, Advanced (see page 101 for details)
Chair: Gregory K. Bergey, M.D.
Neurostimulation: What Do We Need to Know?
Gregory K. Bergey, M.D.
Vagus Nerve Stimulation: Dawn of a New Era
Elinor Ben-Menachem, M.D., Ph.D.
Cerebral Programmed Stimulation
Richard Wennberg, M.D., FRCPC
Lawrence J. Hirsch, M.D.