Presidential Symposium: GABAergic Transmission in Epilepsy
This symposium will focus on the role of gamma-aminobutyric acid (GABA) in the pathophysiology of seizures and will include discussion of its role in a variety of clinical settings, including neonatal seizures, status epilepticus and temporal lobe epilepsy. Current understanding of GABA’s role in epilepsy, including GABAergic plasticity and GABA receptor mutations, will be presented. Treatment decisions, informed by this understanding, including the use of novel medication for neonatal seizures and the imperative for early treatment of status epilepticus with benzodiazepines, will be discussed.
• Establish treatment protocols based on the role of GABA and GABAergic neurons in clinical settings such as status epilepticus and chronic temporal lobe epilepsy
• In treating status epilepticus, use benzodiazepines as first line treatment, initiating benzodiazepines early in treatment
• Use information from translational research on the role of excitatory GABA to manage neonatal seizures
• When evaluating patients with idiopathic (inherited) epilepsies, learner will include recognition of the role of GABAA receptor mutations in developing a differential diagnosis.
Intermediate, Advanced (see page 101 for details)
Chair: Jaideep Kapur, M.D., Ph.D.
Introduction and Overview
Jaideep Kapur, M.D., Ph.D.
GABA and GABAergic Neurons Orchestrate Synchrony in Developing Hippocampal Networks
Yehezkel Ben Ari, Ph.D.
Novel Therapies for Neonatal Seizures
Kevin J. Staley, M.D.
GABA Receptor Trafficking During Status Epilepticus
Howard Goodkin, M.D., Ph.D.
GABAA Receptors and GABAergic Interneurons in Chronic Temporal Lobe Epilepsy
Carolyn R. Houser, Ph.D.
GABAA Receptor Subunit Mutations in Genetic Epilepsies
Robert L. Macdonald, M.D., Ph.D.