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1. Partnership for Pediatric Epilepsy Research
Sanita Agnes Zanelli, M.D. Partnership for Pediatric Epilepsy Research Novel therapeutic option for hypoxia-induced seizures in the neonatal brain One of the most devastating problems babies can encounter around the time of birth is oxygen deprivation to the brain. Understanding how lack of oxygen injures the baby’s brain and leads to seizures is essential for the development of effective treatments for this condition. This work will test whether this channel represents a possible novel ...
2. Partnership for Pediatric Epilepsy Research
Yogendra H. Raol, Ph.D. Partnership for Pediatric Epilepsy Research Potassium channel opener for the treatment of neonatal seizures The risk of seizures is highest in the neonatal period and survivors often experience long-term neurological problems. This research will study the efficacy of flupirtine, a potassium channel opener that may be uniquely effective for the treatment of neonatal seizures due to the important role potassium channels play in controlling brain excitability during ...
3. Partnership for Pediatric Epilepsy Research
Andre Lagrange, M.D., Ph.D. Partnership for Pediatric Epilepsy Research Regulation of Neuronal Development by RNA Editing of GABA-A Receptors GABA is a major developmental signal in the embryonic brain, but is also the primary inhibitory neurotransmitter in the adult brain. RNA editing produces a developmentally regulated change in the protein sequence of a major isoform of the GABA(A) receptor. Based on the spatial and temporal expression patterns of this isoform, it likely plays important...
4. Partnership for Pediatric Research
Mathew Jones, Ph.D. Partnership for Pediatric Research Mechanisms of Childhood Absence Epilepsy in GEFS+ Knock-in Mice. The overall goal of this research is to understand the precise sequence of events in the brain that cause seizures in Childhood Absence Epilepsy (CAE). These studies will reveal how malfunctions in thalamocortical signal processing can give rise to pathological rhythms and will suggest ways to predict, and ideally, prevent absence seizures.
5. Research & Training Workshops
John R. Huguenard, Ph.D. Research & Training Workshops Gordon Research Conference on Mechanisms of Epilepsy and Neuronal Synchronization scheduled for August 2010. American Epilepsy Society 25000.0000 This funding program is intended to provide funding to support workshops for broad-based, national, clinical or scientific audiences and on specific collaborative, consensus or review topics in neuroscience that are novel and creative.
6. Research & Training Workshops
Annamaria Vezzani, Ph.D. & Stephan Ruegg, M.D. Research & Training Workshops Immunity and Inflammation in Epilepsy: Mechanstic Insights and Therapeutic Perspectives meeting to be held in Milano, September 2010 at the Mario Negri Institute for Pharmacological Research. American Epilepsy Society 5000.0000 This funding program is intended to provide funding to support workshops for broad-based, national, clinical or scientific audiences and on specific collaborative, consensus or review topics ...
7. Research & Training Workshops
Yehezkel Ben-Ari, Ph.D. Research & Training Workshops Multiple Facets of GABA in Brain Development Satellite Meeting at the Society for Neuroscience Meeting in 2009 in Chicago American Epilepsy Society 7200.0000 This funding program is intended to provide funding to support workshops for broad-based, national, clinical or scientific audiences and on specific collaborative, consensus or review topics in neuroscience that are novel and creative.
8. Research Initiative Fund
Amy Brooks-Kayal, M.D. Research Initiative Fund Role of p75 Neurotrophin Receptor Signaling in Epileptogenesis American Epilepsy Society 50000.0000 1 year funding beginning January 2010 Abstract: We propose to determine if animals can be rescued from epilepsy development and/or progression via blockage of BDNR-p75 neurotrophin receptor (NTR) mediated activation of the JAK/STAT pathway using novel, small molecule p75NTR ligands.
9. Research Infrastructure Award
W. Curt LaFrance, Jr., M.D., M.P.H. Research Infrastructure Award Establish a Collaborative Multicenter Research Program on NES American Epilepsy Society/Epilepsy Foundation 50000.0000 Funded in January 2010 Abstract: The 2007 NINDS Curing Epilepsy II conference identified developing treatments for psychogenic nonepileptic seizures (PNES) as one of its benchmarks. Small munticenter pilots are not covered by current mechanisms and this funding program will help establish the collaborative ...
10. Susan Spencer Fellowship/Early Career Physician-Scientist Award
Yoshimi Sogawa, M.D. Susan Spencer Fellowship/Early Career Physician-Scientist Award Computerized EEG Analysis Methods to Create the Algorithm to Detect Subtle Features on EEG Milken Family Foundation/American Epilepsy Society 50000.0000 Funding begins January 2010


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