Search Current Research
| 1 - 11 of 338 | Your Search Criteria: "Research" |
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Predoctoral Research Training Fellowship
Marcel Paz Goldshen-Ohm Predoctoral Research Training Fellowship "Inter-subunit communication in the GABAA receptor." The GABAA receptor is the major inhibitory neurotransmitter receptor in the central nervous system, and plays an important role in shaping the activity of neuronal networks required for normal cognitive function. Several mutations in this receptor are associated with epilepsy in humans, one of which may disrupt communication between the receptor? |
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Predoctoral Research Training Fellowships
The calcium channel serves as a pore in the cell membrane through which calcium flows. Given the important role calcium channels serve in absence epilepsy, experiments are needed to develop an understanding of the portions of these channels that determine this type of cell firing. To address this, mutant channels that are missing parts of the normal channel will be created and tested for a number of properties, namely, how much current flows through the mutant channel, how long the channel ... |
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Predoctoral Research Training Fellowship
Daniel Tice Barkmeier Predoctoral Research Training Fellowship "Translating human gene expression profiles of interictal spiking into a rat model" In addition to seizures, patients with epilepsy have another type of abnormal brain activity called 'interictal spikes.' To determine whether interictal spiking alone is sufficient to induce the gene expression changes seen in epileptic brain areas, this project will create an animal model of interictal spiking. The hypothesis is that interictal ... |
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Research & Training Fellowships for Clinicians
William Charles Stacey, M.D., Ph.D. Research & Training Fellowships for Clinicians Improving the Efficacy of Antiepileptic Devices: From Cellular Models to Bedside Preceptor: Brian Litt, M.D. Lay Summary: The goal of this project is to create a computer simulation of a section of epileptic brain. This simulation will then be used to test how an electrical stimulus can be used to stop seizures from occurring. The results of these simulations will later be used to guide development of future,... |
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Research & Training Fellowships for Clinicians
Susan J. Shaw, M.D. Research & Training Fellowships for Clinicians Investigational physiologic/anatomic studies in patients undergoing clinical investigations for neurological disorders Preceptor: Nathan E. Crone, M.D. Lay Summary: When patients with epilepsy have surgery to control their seizures, it is important to know which areas of the brain are needed for speech so that the surgery will not damage them. This research project uses three new ways of mapping the brain to improve our ... |
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Research & Training Fellowships for Clinicians
Beth Ami Leeman Research & Training Fellowships for Clinicians A trial of memantine for the treatment of verbal memory dysfunction in patients with left temporal lobe epilepsy Preceptor: Steven Schachter, M.D. Lay Summary: Many people with seizures have difficulty remembering things and doing simple thinking tests. This study looks at whether memantine (also called Namenda), can improve memory for words in people with left temporal lobe epilepsy. This drug is used for the memory loss caused... |
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Research & Training Fellowships for Clinicians
Sara Krause Inati Research & Training Fellowships for Clinicians Epilepsy Monitoring with Subpial Micro-Electrode Array: Improved Identification of the Epileptogenic Zone Preceptor: Ronald G. Emerson, M.D. Lay Summary: This research utilizes a very small grid of electrodes called a microelectrode array to record electrical activity in the brains of patients undergoing evaluation for epilepsy surgery. Careful analysis of the location of the groups of neurons, and of the patterns of their ... |
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Research & Training Fellowships for Clinicians
Daniel Friedman Research & Training Fellowships for Clinicians The role of entorhinal cortex in seizures and epileptogenesis in an in vivo model of temporal lobe epilepsy. Preceptor: Helen Sharfman, Ph.D. Co-Preceptor: Frank Gilliam, M.D., M.P.H Lay Summary: Despite over a century of study, the link between changes in brain structure and seizures in temporal lobe epilepsy is not clear. The study’s results will improve our understanding of the brain circuits responsible for temporal lobe ... |
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Research & Training Fellowships for Clinicians
Gabriel Ustin Martz Research & Training Fellowships for Clinicians Intracerebral Infusion to Treat Limbic Epilepsy Preceptor: Edward H. Bertram, M.D. Summary: Epilepsy is a very common disease that affects up to 1% of people. This may be because the drug causes side effects, or because it isn’t reaching the part of the brain causing the seizures. Putting small amounts of drug right into a key part of the brain may be able to stop the seizure without causing the side effects that occur when ... |
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Research Grants
Jokubus Ziburkus Research Grants The role of neuromodulators in inhibitory and excitatory synchrony and epileptiform activity pattern formation Summary: Epileptic seizures have different electrical, emotional, and physical expression even in the same individual. Levels of arousal (sleepy or alert) are dictated by slow acting substances called neuromodulators. We propose to explain the mechanisms by which neuromodulators change electrical signatures of epileptic seizures. |
| 1 - 11 of 338 | Your Search Criteria: "Research" |