Archived AES Symposia 2006
Hot Topics Symposium
Program Length: 2 hrs 19 min
The Hot Topics Symposium consists of five presentations in diverse basic science and clinical topics. The presentations will cover areas that represent either a high level of current research activity or those that identify a need for expanded research to meet the challenge posed by present limitations in the prevention, diagnosis and treatment of epilepsy. This symposium also provides a forum to update the audience on ongoing studies that have important early findings of interest: seizure prediction, imaging of the epileptic brain, psychobiological profile of epileptic patients, and novel approaches in rational design of antiepileptic drugs.
At the conclusion of this activity, participants should be able to:
- Explain computational methods that allow mapping of entire cerebrum in three-dimensional space to detect cortical and subcortical deficits in the epileptic brain; demonstrate how new brain mapping techniques extend previous region of interest volumetric studies to map the precise location of atrophy and shape deviation in selected structures.
- Discuss cognitive and psychiatric status of epileptic patients at time of diagnosis; based on the known progression of cognitive and psychiatric problems in children and adults with epilepsy, institute prompt, appropriate interventions.
- Discuss pharmacology of G-protein coupled receptors (GPCR) and Toll-like receptors (TLR). Evaluate these receptors as targets for new antiepileptic drugs. Provide examples of anticonvulsant efficacy of the compounds acting at GPCR and TLR.
- Demonstrate prospective seizure prediction from prolonged human data sets; identify mechanisms underlying seizure precursors; discuss clinical implementation of seizure prediction algorithms.
- Describe evidence both in favor of and against the hypothesis that prolonged febrile seizures cause hippocampal sclerosis and temporal lobe epilepsy; compare patterns of MRI abnormalities following febrile seizures with the pathology in hippocampal sclerosis.
Neurologists, epileptologists, neurosurgeons, psychiatrists, allied health professionals and pharmacists.
Co-chairs: Raman Sankar, M.D., Ph.D. and Andrey M. Mazarati, M.D., Ph.D.
Advancements in Brain Mapping: Virtual Dissection of the Epileptic Brain
Jack Lin, M.D.
Timing and Progression of Neurobehavioral Complications in Epilepsy
Bruce Hermann, Ph.D.
G Protein Coupled Receptors and Toll-Like Receptors as Targets for Antiepileptic Drugs of the Future
Tamas Bartfai, Ph.D.
Mapping and Targeting Intervention to Stablize Epileptic Networks
Brian Litt, M.D.
Selective Regional Distribution of Hippocampal MRI Abnormality Following Febrile Status Epilepticus
Solomon L. Moshé, M.D.
Disclaimer: Opinions expressed with regard to unapproved uses of products are solely those of the faculty and are not endorsed by the American Epilepsy Society or any manufacturers of pharmaceuticals.