Archived AES Symposia 2006
Merritt-Putnam Symposium - Mapping Epileptic Circuitry
Program Length: 2 hrs 56 min
New tools to map the microanatomy of seizures in ever greater detail are pinpointing neural pathways that mediate specific brain synchronization patterns and helping clinicians to stratify patients into distinct clinical entities and select optimal therapy. This symposium will review state of the art approaches that are paving the way to more precise definitions of which circuits are discharging abnormally in individual patients, how seizure networks are mapped at the cellular level in the laboratory, and what the future holds for integrating various methods of imaging brain function in epilepsy patients. Speakers will discuss how dense array analysis of scalp-recorded EEG potentials can now reveal deeper focal regions of hypersynchrony within generalized seizure disorders. Other studies pairing the EEG with functional imaging modalities such as BOLD, SPECT, PET, and MEG can define brain regions where the biochemical and electrical abnormalities underlying seizures are matched. Cellular neurophysiology and molecular methods of detecting abnormal gene expression in neuronal networks allow pathways for seizure progression to be traced in experimental models. Finally, the program will close with a look at how functional imaging combined with pharmacological challenges may allow new ways of characterizing individual differences in the epileptic brain.
At the conclusion of this activity, participants should be able to:
- Identify new quantitative methods of analyzing high density EEG electrode signals to localize epileptic foci within a patient’s brain and explain how to apply these methods to patients in your practice
- Evaluate the utility of simultaneous functional brain imaging with EEG monitoring to detect seizure activity and describe clinical situations for which this method of monitoring is appropriate and will supply important information to guide diagnosis or treatment
- Describe the correlation between neurochemical and electrophysiological information about seizure foci in deep brain structures of epilepsy patients, and apply this information to formulate clinical care plans
- Review molecular methods for identifying neurons affected by seizure activity in experimental models of epilepsy and summarize how these emerging techniques may be applied to patients in your clinical practice
- Demonstrate how emerging tools in functional neuroimaging may increase diagnostic precision and predict drug management of patients with epilepsy.
Neurologists, neurosurgeons, neuroradiologists, neuropharmacologists, and neurophysiologists.
Chair: Jeffrey L. Noebels, M.D., Ph.D.
Dense Array Electroencephalography of Epilepsy
Mark D. Holmes, M.D.
Molecular and Diffusion Tensor Neuroimaging of Epileptic Networks
Harry T. Chugani, M.D.
Mapping Seizure Pathways in the Temporal Lobe
Dan C. McIntyre, Ph.D.
Glutamate Metabolism and Imaging Energy with High Field Strength Spectroscopy
Dennis D. Spencer, M.D.
Human Epileptic Networks Studied with Combined EEG and fMRI
Jean Gotman, Ph.D.
Disclaimer: Opinions expressed with regard to unapproved uses of products are solely those of the faculty and are not endorsed by the American Epilepsy Society or any manufacturers of pharmaceuticals.