Archived AES Symposia 2007
AET Symposium: Generic Antiepileptic Drug Substitution - Sorting Out the Myth from the Science
Program Length: 2 hrs 49 min
This symposium is designed to specifically address what is known and what is not known about generic antiepileptic drugs. As more brand-name antiepileptic drugs come off patent and patients are started initially or moved to generics, clinicians must be well versed about the potential risks associated with generic substitution. Moreover, physicians and patients should make informed decisions based on scientific fact rather than myth and speculation. This symposium will address these and other factors important to the practicing neurologist whose patient is faced with the option of generic substitution of antiepileptic drugs.
- Discuss regulatory guidelines, laws regarding bioequivalence, and the positions of professional associations regarding generic drug substitution for the management of patients who are started on generic drugs or switched from brand to generic formulations
- Assess the immediate and long-term effects of breakthrough seizures and adverse events on the brain that may result from changes in antiepileptic drug formulation
- Assess the medical implications for the patient of breakthrough seizures and adverse events that may result from changes in antiepileptic drug formulation
- Analyze the current medical literature and describe ways in which future clinical trials could be designed to assess the impact of generic substitution in order to avoid patient complications.
Neurologists, pharmacists, nurses, neuroscientists, neurosurgeons, and other healthcare professionals involved in the care of patients with epilepsy or who conduct research in epilepsy
Introduction and Opening Remarks
Tracy Glauser, M.D; H White, Ph.D
Generics 101: Fact vs. Fiction
Jacquelyn Bainbridge, Pharm.D., FCCP; Russell Katz, M.D
Basic Science: The Effects of Breakthrough Seizures and Adverse Events on the Brain
Asla Pitkänen, M.D., Ph.D., D.Sc.
The Clinical Perspective: What Are the Medical Implications of Breakthrough Seizures and Adverse Events on the Patient and Clinician?
Michael Privitera, M.D
Seeking the Solution: Methods and Madness
Blaise Bourgeois, M.D
This program and its repurposing on the AES Web site is supported by an educational grant from UCB, Inc.
Disclaimer: Opinions expressed with regard to unapproved uses of products are solely those of the faculty and are not endorsed by the American Epilepsy Society or any manufacturers of pharmaceuticals.