Archived AES Symposia 2007
Merritt-Putnam Symposium: Post-Traumatic Epilepsy - Treatable Epileptogenesis?
Program Length: 2 hrs 46 min
Epilepsy following traumatic brain injury remains one of the major clinical examples of de novo epileptogenesis. Post-traumatic epilepsy affects all age groups, and can be a result of combat injury. To date, no therapies have been clinically employed that prevent post-traumatic epilepsy. Recent clinical research points to new diagnostic tools that may improve detection of epilepsy risk in this population. Experimental models of epilepsy are revealing pathophysiologic mechanisms that shed light on new therapeutic targets for the prevention of epilepsy and disease modification. This symposium will provide an update of relevant translational research and clinical trials that are transforming the management of traumatic brain injury and post-traumatic epilepsy.
- Describe the epidemiology of post-traumatic epilepsy and the clinical evidence for epileptogenesis in this patient population to assist in the identification of patients at risk for epilepsy
- Discuss the outcomes of past clinical trials for the prevention (or prevention and treatment) of post-traumatic seizures and measures that have been effective to guide new research and treatment considerations
- Recognize the clinical, electrophysiologic, and neuroradiologic features of post-traumatic epilepsy in humans, and how these may direct future development of antiepileptogenic therapies to improve patient outcomes
- Assessing data from animal models that investigate traumatic brain injury—including the development of epilepsy in some of these models, phenotypes of post-traumatic epilepsy, and preclinical treatments that have improved the recovery after traumatic brain injury—explain their implications in the prevention of post-traumatic epilepsy
- Identify recent advances in basic research pertaining to the pathophysiology of epilepsy and potential approaches to prophylaxis for epilepsy in patients who have experienced cortical injury
- Integrate basic science discoveries into concrete clinical trials for the development of therapeutic measures to prevent post-traumatic epilepsy in patients who are at risk.
Epileptologists, neurologists, neuroscientists, pharmacists, residents, and other healthcare professionals involved in the care of persons with epilepsy
Post-Traumatic Epilepsy — Treatable Epileptogenesis?
Frances Jensen, M.D
Epilepsy After Head Injury – An Overview
Daniel Lowenstein, M.D
Preventing and Treating Post-Traumatic Seizures: The Human Experience
Nancy Temkin, Ph.D
Post-Traumatic Epilepsy: The Endophenotypes of a Human Model of Epileptogenesis
Ramon Diaz-Arrastia, M.D., Ph.D
From Traumatic Brain Injury to Post-Traumatic Epilepsy: What Animal Models Tell About the Process and Treatment Options
Asla Pitkänen, M.D., Ph.D
Epileptogenesis Following Cortical Injury: Cellular and Molecular Mechanisms as Targets for Potential Prophylaxis
David Prince, M.D
Post-Traumatic Epilepsy: The Challenge of Translating Discoveries in the Laboratory to Pathways to a Cure
Marc Dichter, M.D., Ph.D
This program and its repurposing on the AES Web site is supported by an educational grant from Pfizer Inc.
Disclaimer: Opinions expressed with regard to unapproved uses of products are solely those of the faculty and are not endorsed by the American Epilepsy Society or any manufacturers of pharmaceuticals.