Archived AES Symposia 2007
Presidential Symposium: Found in Translation - New Targets for Therapies
Program Length: 1 hrs 22 min
Epilepsy research scientists and clinicians are collaborating in translating scientific discoveries into new therapies for the intractable epilepsies. Discoveries of clinical researchers are guiding the development of relevant animal models. Studies in these models are leading to the identification of what appear to be key molecular steps in the genesis of epilepsy. These molecular mechanisms provide new targets for the development of rational therapies, which can be tested in these same models. As an example of the progress being made, this symposium will review the most recent studies of the consequences of prolonged febrile seizures in children. Potential targets for new therapies that have been discovered in models of febrile seizures, head injury, neonatal seizures, and kindling will be discussed.
- Describe an area of the brain impacted in some children by prolonged febrile seizures and the anatomical changes observed by magnetic resonance imaging that may inform targets for therapeutic research
- Discuss potential new antiepileptogenic drug targets in the cannabinoid signaling pathway that regulate transmitter release and how they may be applied to treatment of febrile seizures
- Identify a cellular/molecular mechanism involved in seizure generation or epileptogenesis that is unique to the immature nervous system and its application to seizure control in young children
- Define the role of the neurotrophin receptor, TrkB, in epileptogenesis as seen in an animal model of temporal lobe epilepsy and how it may play a part in antiepileptogenic treatment for children.
Epileptologists, neurologists, neuroscientists, pharmacists, residents, and other healthcare professionals involved in the care of persons with epilepsy
Found in Translation - New Targets for Therapies
John Swann, Ph.D
Introduction and Opening Remarks
John Swann, Ph.D
Febrile Status Epilepticus: Creating a Target for Therapy?
Darrell Lewis, Jr., M.D
Cannabinoid Receptors as Novel Antiepileptogenic Drug Targets
Ivan Soltesz, Ph.D
Unique Targets for Seizure Control and Antiepileptogenesis in the Immature Brain
Frances Jensen, M.D
Disclaimer: Opinions expressed with regard to unapproved uses of products are solely those of the faculty and are not endorsed by the American Epilepsy Society or any manufacturers of pharmaceuticals.