Archived AES Symposia 2007
Symposium: What Is a Seizure?
Program Length: 2 hrs 37 min
This symposium addresses the question, "What is a Seizure?", from a number of different perspectives. Seizures in simpler nervous systems of worms, flies and fish will be described to help establish fundamental features. Modeling and experimental data from brain slice experiments will be presented to illustrate mechanisms of interictal-to-ictal transitions, fast oscillations, and seizure spread and termination. In vivo data from a rat model of temporal lobe epilepsy will reveal changes in hippocampal activity that precede seizure onset by minutes. Recordings from patients will show novel broadband data and identify clinically relevant questions.
- Recognize fundamental features of seizures generated in simpler nervous systems to improve accurate identification of seizures in patients
- Define basic mechanisms of seizures and EEG phenomenology, including roles of cellular intrinsic properties, synaptic interactions, and electrical coupling via gap junctions, in seizure generation, propagation, and termination to reveal potential targets for development of new therapeutic interventions
- Identify potential relationships between generation of interictal and ictal activity within a given neural network to understand clinical significance of interictal EEG spikes
- Recognize that significant changes in neuronal activity precede onset of spontaneous limbic seizures in vivo, which offers potential new approaches for predicting seizures to improve treatment and patient quality of life
- Describe limitations of commonly used EEG recording technology for detecting high-frequency events related to seizure onset
- Identify what constitutes a seizure in patients evaluated with EEG recording according to scientific and clinical criteria or understand points of debate on this topic so that unnecessary treatment based on incorrect interpretation of electrographic data is avoided.
Neurologists, epilepsy researchers, and pharmacists
What Is a Seizure?
Paul Buckmaster, D.V.M., Ph.D; Brian Litt, M.D
Introduction and Opening Remarks
Brian Litt, M.D
Seizures in Simpler Nervous Systems
Scott Baraban, Ph.D
Seizures in Brain Slices: Recording CA3
Kevin Staley, M.D
Seizures in Brain Slices: Fast Oscillations and Seizure Phenomena in Neocortex In Vitro
Roger Traub, M.D
Seizures in Rats: Preictal Hippocampal Activity in a Model of Temporal Lobe Epilepsy
Paul Buckmaster, D.V.M., Ph.D
Seizures in Patients: High Spatio-temporal Resolution Recording in Humans
Gregory Worrell, M.D., Ph.D
Seizures in Patients: Clinical Translation of Basic Questions
Brian Litt, M.D
Disclaimer: Opinions expressed with regard to unapproved uses of products are solely those of the faculty and are not endorsed by the American Epilepsy Society or any manufacturers of pharmaceuticals.