Archived AES Symposia 2008
AET Symposium: When Monotherapy Fails
Program Length: 27 min
For a significant percentage of patients with epilepsy, treatment with 1 antiepileptic drug (AED) is often insufficient to achieve seizure control. For such patients providing optimal care includes early recognition that AED monotherapy is failing, as well as quick and systematic implementation of a preferred combination therapy or neurosurgical approach. This symposium will provide a comprehensive overview of the issues associated with monotherapy failure. Presentations will discuss criteria for defining monotherapy failure, selection of rational polytherapy and appropriate surgical approaches, data from the recently completed SANTE trial, and new therapies that are in late-stage clinical development.
- Evaluate patients for therapeutic failure based on established guidelines
- In a patient who fails multiple trials of AED monotherapy, select appropriate combination therapy or surgical interventions based on best available evidence
- Identify types of epilepsy patients most likely to benefit from third generation AEDs that are in late-stage clinical development, should they become available in the future.
Neurologists, nurses, nurse practitioners, physician assistants and clinical pharmacists
Co-Chairs: H. Steve White, Ph.D. and Tracy A. Glauser, M.D.
Introduction and Opening Remarks
H. Steve White, Ph.D.
What Defines Monotherapy Failure?
Katherine Holland, M.D., Ph.D.
Is There Such a Thing as Rational Polypharmacy: What Criteria Should Be Employed When Considering a Combination Approach?
Tracy A. Glauser, M.D.
Can Animal Models Predict Effective Combination Therapies?
F. Edward Dudek, Ph.D.
New AEDs on the Horizon
Meir Bialer, Ph.D., M.B.A.
Non-Pharmacological Approach: Release of the "Stimulation of the Anterior Nucleus of the Thalamus in Epilepsy (SANTE)" Trial Results
Robert S. Fisher, M.D., Ph.D.
Repurposing of the program is supported by an educational grant from UCB, Inc.
Disclaimer: Opinions expressed with regard to unapproved uses of products are solely those of the faculty and are not endorsed by the American Epilepsy Society or any manufacturers of pharmaceuticals.