Archived AES Symposia 2008
Childhood Absence Epilepsy Symposium: New Insights Into an Old Syndrome
Program Length: 21 min
Childhood absence epilepsy (CAE) accounts for 10-15% of all childhood epilepsies and is commonly misperceived as a "benign" epilepsy syndrome. Despite its seemingly well characterized features, patients with this genetically complex syndrome demonstrate variable response to therapy, exhibit cognitive deficits, demonstrate long-term psychosocial difficulties, and have variable remission rates. Similar to other epilepsies, the current therapeutic approach for children with CAE is empiric.
This symposium will provide a comprehensive overview of the issues associated with the clinical presentation, underlying genetics, evidence based treatment and co-morbidities associated with CAE. Presentations will focus on:
- Current understanding of the phenotypes, epidemiology and outcome of CAE,
- Genotypes associated with CAE and other epilepsies involving absence seizures
- Results of the NIH-funded randomized double-blind comparative trial of 3 AEDs for initial treatment of CAE
- Co-existing neuropsychological deficits noted in patients with CAE
- Analyze variability in CAE phenotypes in order to refine a diagnostic strategy for CAE
- Counsel patients with CAE and their parents on the genetic aspects of the syndrome
- Use newly-available data from the comparative NIH-funded trial to select optimal initial AED therapy for patients with CAE
- Identify comorbidities in children with CAE in order to affect positive outcomes.
Neurologists, nurses, nurse practitioners, physician assistants, clinical pharmacists and pediatricians
Chair: Tracy A. Glauser, M.D.
Introduction and Opening Remarks
Tracy A. Glauser, M.D.
The Phenomenology and Epidemiology of Childhood Absence Epilepsy
Anne T. Berg, Ph.D.
The Genetics of Absence Seizures When Part of Idiopathic Generalized Epilepsies
Ingrid E. Scheffer, Ph.D., FRACP, M.B.B.S.
The NIH Childhood Absence Epilepsy Trial: Results from a Double-Blind Randomized Comparative Trial
Tracy A. Glauser, M.D.
Pre-Existing and Persisting Cognitive Deficits in Children with Childhood Absence Epilepsy
David Masur, Ph.D., A.B.P.P.
Disclaimer: Opinions expressed with regard to unapproved uses of products are solely those of the faculty and are not endorsed by the American Epilepsy Society or any manufacturers of pharmaceuticals.