Archived AES Symposia 2008
Merritt-Putnam Symposium: Epileptogenic Cortical Dysplasia: Emerging Trends in Diagnosis, Treatment and Pathogenesis
Program Length: 2 hrs 35 min
Focal cortical dysplasias are a leading cause of intractable epilepsy in children and adults, and are detected with increasing frequency due to improved neuroimaging. Due to lack of efficacy of antiepileptic drugs in many patients, epilepsy surgery remains a mainstay of therapy for these disorders. Clinical and experimental studies have revealed that these disorders may be on a spectrum, sharing common features, and potentially, mechanisms of epileptogenesis. This symposium will review the considerable advances in diagnostic neuroimaging and neurophysiological investigation and discuss state-of-the art diagnostic methods. The field is also rapidly advancing in its understanding of the genetics as well as the molecular underpinnings of these human disorders, and recent work employing human biopsy tissue has revealed alterations in cellular signaling and neurotransmitter receptors. Animal models are being generated that recapitulate aspects of specific dysplasia syndromes, and are showing similar genetic and cellular alterations. Preclinical trials of novel therapies are revealing promising new therapeutic directions. The impact of these recent advances on epilepsy surgery will be discussed, including new methods of intraoperative assessment and investigational studies.
- Describe recent advances in the pathophysiology, diagnostics, and therapeutics for patients with cortical dysplasia
- Implement use of new imaging strategies to diagnose and monitor patients with cortical dysplasia
- Counsel patients diagnosed with cortical dysplasia and their caregivers on the anticipated benefits and potential limitations of therapy in order to help them set realistic expectations
- Increase the frequency with which timely referral is made to specialist care for patients with cortical dysplasia.
Clinicians, nurses, clinical researchers, basic scientists and pharmacists
Chair: Frances E. Jensen, M.D.
Introduction and Opening Remarks
Frances E. Jensen, M.D.
Focal Cortical Malformations: Seizures, Signaling and Sequencing
Peter B. Crino, M.D., Ph.D.
New Directions in Clinical Imaging of Cortical Dysplasias
Ellen Grant, M.D.
Clinical, Functional, and Neurophysiologic Assessment of Dysplastic Cortical Networks: Implications for Higher Cortical Function and Surgical Management
Michael S. Duchowny, M.D.
From Human Tissue to Animal Models: Insights into the Pathogenesis of Cortical Dysplasia
Gabriella D'Arcangelo, Ph.D.
Animal Models of Focal Cortical Dysplasia and Tuberous Sclerosis Complex: Recent Progress Towards Clinical Applications
Michael Wong, M.D., Ph.D.
Current and Future Challenges in the Surgical Treatment of Epilepsy Patients with Cortical Dysplasia
Gary W. Mathern, M.D.
Repurposing of the program is supported by an educational grant from Pfizer Inc.
Disclaimer: Opinions expressed with regard to unapproved uses of products are solely those of the faculty and are not endorsed by the American Epilepsy Society or any manufacturers of pharmaceuticals.