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Brain formation pattern shows why early trauma may leave no clues

Medical News Today - Thu, 02/04/2016 - 05:00
Some of the earliest nerve cells to develop in the womb shape brain circuits that process sights and sounds, but then give way to mature networks that convert this sensory information into thoughts.
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International recommendation for a comprehensive neuropathologic workup of epilepsy surgery brain tissue: A consensus Task Force report from the ILAE Commission on Diagnostic Methods

Epilepsia - Wed, 02/03/2016 - 06:35

Epilepsy surgery is an effective treatment in many patients with drug-resistant focal epilepsies. An early decision for surgical therapy is facilitated by a magnetic resonance imaging (MRI––visible brain lesion congruent with the electrophysiologically abnormal brain region. Recent advances in the pathologic diagnosis and classification of epileptogenic brain lesions are helpful for clinical correlation, outcome stratification, and patient management. However, application of international consensus classification systems to common epileptic pathologies (e.g., focal cortical dysplasia [FCD] and hippocampal sclerosis [HS]) necessitates standardized protocols for neuropathologic workup of epilepsy surgery specimens. To this end, the Task Force of Neuropathology from the International League Against Epilepsy (ILAE) Commission on Diagnostic Methods developed a consensus standard operational procedure for tissue inspection, distribution, and processing. The aims are to provide a systematic framework for histopathologic workup, meeting minimal standards and maximizing current and future opportunities for morphofunctional correlations and molecular studies for both clinical care and research. Whenever feasible, anatomically intact surgical specimens are desirable to enable systematic analysis in selective hippocampectomies, temporal lobe resections, and lesional or nonlesional neocortical samples. Correct orientation of sample and the sample's relation to neurophysiologically aberrant sites requires good communication between pathology and neurosurgical teams. Systematic tissue sampling of 5-mm slabs along a defined anatomic axis and application of a limited immunohistochemical panel will ensure a reliable differential diagnosis of main pathologies encountered in epilepsy surgery.

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Treatment non-adherence in pseudo-refractory epilepsy

Epilepsy Research Journal - Wed, 02/03/2016 - 00:00
Poor adherence to prescribed treatment is considered one of the most serious obstacles to the management of epilepsy (Faught, 2012; Samsonsen et al., 2014). It is of major importance to acknowledge that uncontrolled epilepsy does not necessarily reflect drug-resistant epilepsy. Recently, the International League Against Epilepsy defined drug-resistant epilepsy as uncontrolled seizures in spite of adequate trials of at least two tolerated, appropriately chosen and appropriately used antiepileptic drug (AED) schedules (Kwan et al., 2010).
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