Read the latest medical research on epilepsy and seizures including new treatments and potential cures under development.
Updated: 54 min 30 sec ago
Lack of oxygen, not excessive stimulation, cause for half of seizure-related brain damage in epilepsy
Neuronal degeneration is the most severe long-term consequence of repetitive seizures in patients with epilepsy, which until now was thought to be primarily caused by excitotoxicity, or over-stimulation of the neurons. New findings indicate hypoxia, or lack of oxygen, due to abnormal blood flow may be to blame for as much as half the neuronal death caused by the condition.
Prolonged epileptic seizures may cause serious problems that will continue for the rest of a patient’s life. As a result of a seizure, neural connections of the brain may be rewired in an incorrect way. This may result in seizures that are difficult to control with medication. Mechanisms underlying this phenomenon are not entirely known, which makes current therapies ineffective in some patients.
In a small phase I and II clinical trial, researchers and colleagues elsewhere found that the high-fat, low-carbohydrate ketogenic diet was a safe and effective treatment option for the majority of adults experiencing a relatively rare, often fatal and always severe form of epilepsy marked by prolonged seizures that require medically induced comas to prevent them from further damaging the body and the brain.
The MRI-guided laser ablation method is far less invasive and time-consuming than conventional surgery and has produced good results for people with medial temporal lobe epilepsy, report investigators.
Previous studies have shown that anti-epilepsy medicine may lead to congenital malformations in the fetus and that the use of anti-epilepsy medicine during pregnancy affects the development of the brain among the children. There is still a lack of knowledge in the area about the general health of children who are exposed to anti-epilepsy medicine in fetal life. But this new study is generally reassuring for women who need to take anti-epilepsy medicine during their pregnancy.
New clues to the link between Nodding syndrome, a devastating form of pediatric epilepsy found in specific areas of east Africa, and a parasitic worm that can cause river blindness have now been uncovered by researchers. The study suggests that the mysterious neurological disease may be caused by an autoimmune response to the parasitic proteins.
'Bench-to-bedside' describes research that has progressed from basic science in animal models that has led to therapies used in patients. Now, a study describes what could be considered a direct 'aquarium-to-bedside' approach, taking a drug discovered in a genetic zebrafish model of epilepsy and testing it, with promising results, in a small number of children with the disease.
There are important, long-term gains from hastening the processes around surgical interventions against epilepsy -- before the disease has had too much negative impact on brain functions and patients' lives. These are some of the findings of a thesis for which more than 500 patients were studied and followed up.
Before epilepsy surgery, doctors may consider using brain imaging to locate language and memory functions in the brain instead of the more invasive procedure that is commonly used, according to a guideline. It is the first evidence-based guideline that systematically reviewed all evidence for such an evaluation.
Several genes implicated in rare forms of pediatric epilepsy also contribute to common forms of the disorder, new research has found.
New research proposes an explanation for the occurrence of epileptic seizures as a result of the exposure to certain stimuli.
Researchers used a rodent model to discover that shifting the firing pattern of a particular set of brain cells is all it takes to initiate, or to terminate, an absence seizure.
Neural stem cells have been found in epileptic brain tissue—outside the regions of the brain where they normally reside. In a group of patients who underwent surgery for epilepsy, over half had stem cells where healthy individuals do not have them, according to a study.
Scientists have discovered a gene network in the brain associated with epilepsy. The team believes the discovery may lead to more treatments for the condition.
Epilepsy patients who want to learn how to manage their own unique symptoms can now get individualized information via tablet computer through a new research project.
For most women who have epilepsy, continuing their medication during pregnancy is important for their health. Over the last 25 years, research has shown that children exposed to these medications in the womb can be at a higher risk of having a malformation or birth defect.
A genetic change in the protein eEF2K creates resistance to epileptic attacks, thereby creating the possibility of a new treatment for the disease, show the surprising results of a new study.
Mental disorders and physical diseases frequently go hand in hand. For the first time, psychologists have identified temporal patterns in young people: arthritis and diseases of the digestive system are more common after depression, while anxiety disorders tend to be followed by skin diseases.
The potential reasons why many patients with severe epilepsy still continue to experience seizures even after surgery have been outlined in a new report. Epilepsy continues to be a serious health problem and is the most common serious neurological disorder. Medically intractable temporal lobe epilepsy (TLE) remains the most frequent neurosurgically treated epilepsy disorder.
A new study shows a link between mothers with rheumatoid arthritis and children with epilepsy. Rheumatoid arthritis (RA) is an autoimmune disease that causes the body’s own immune system to attack the joints. It differs from osteoarthritis, which is caused by wear and tear on the joints.