Epilepsy Research Journal
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Status epilepticus (SE) carries a risk of major morbidity or mortality (Lowenstein and Alldredge, 1998; Rossetti and Lowenstein, 2011). There are many treatments for SE, including benzodiazepines such as diazepam (DZP) and lorazepam (Meierkord et al., 2006, 2010; Brophy et al., 2012). However, 30–43% of SE cases become refractory to drugs (Holtkamp et al., 2005; Mayer et al., 2002). Prolonged seizure results in neuronal injury, neuronal death, and alteration of neuronal networks that can result in death or spontaneous recurrent seizures (SRS) and cognitive impairment that will impact the patient’s whole life (Curia et al., 2014; Trinka et al., 2015).
Phenylalanine derivatives with modulating effects on human α1-glycine receptors and anticonvulsant activity in strychnine-induced seizure model in male adult rats
In central, as well as peripheral, nervous system, GLY functions as a neurotransmitter at inhibitory synapses, where it activates strychnine-sensitive glycine receptors (GLYRs) which are composed of five subunits (α1-4 and β) (Lynch, 2004) and belong to pentameric Cys-loop ligand-gated ion channel superfamily (Cys-loop LGICs)(Castro et al., 2012; Lester et al., 2004).