Epilepsy Research Journal

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Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model

Tue, 08/23/2016 - 00:00
Epilepsy is a neurological disorder characterized by spontaneous and recurrent seizure episodes (Fisher et al., 2005) that affects between 1–2% of the world population. So far, there is no cure and the treatments with anticonvulsants are not totally efficacious for the different types of epilepsy (López-Hernández et al., 2005). The side effects of tolerance, dependence, risk of death, physical injury (due to the episodes), cerebral damage and induction of psychotic reactions become a problem for clinical treatment.
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Subjective memory complaints in patients with epilepsy: The role of depression, psychological distress, and attentional functions

Thu, 08/18/2016 - 00:00
While objective memory dysfunctions have been thoroughly investigated in patients with epilepsy, assessment of subjective memory complaints (SMC) remains challenging. Former studies have demonstrated an impact of patients’ depressive mood on SMC. However, the impact of more general psychological distress and cognitive functioning in non-memory domains on SMC has only received little attention so far. We therefore sought to determine the factors which may particularly predict SMC in a sample of patients with focal epilepsy (n=99) who accomplished (1) a comprehensive neuropsychological assessment, (2) a subjective memory questionnaire, and (3) scales of self-rated depressive mood and psychological distress.
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Tolerability, safety, and efficacy of adjunctive brivaracetam for focal seizures in older patients: A pooled analysis from three phase III studies

Thu, 08/18/2016 - 00:00
Epilepsy is common in older adults; causes of new-onset epilepsy at older ages include cerebrovascular disease, dementia, Alzheimer’s, brain tumor, primary neurodegenerative disorders, and traumatic head injury (Brodie et al., 2009; Pugh et al., 2009). The incidence of treated epilepsy has been estimated at 80.8 per 100,000 in the general population, rising to 85.9 per 100,000 in those aged 65–69 years, and 135.4 per 100,000 in people ≥85 years (Wallace et al., 1998). In addition to older patients with new-onset epilepsy, the population of older adults with epilepsy also includes those who have been treated for many decades.
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