Clinical Guidance

Keeping current on evidence-based clinical guidance is critical for epilepsy professionals to provide quality care to patients and families. This page provides links to information about AES processes for systematic review and clinical guidance development, as well as epilepsy-related resources such as guidelines, practice parameters, and other clinical guidance developed by AES, other societies, or collaboratively that may be useful for health care professionals.


AES Clinical Practice Guideline Development Manual (2020)

This manual outlines principles and processes intended to guide AES-led workgroups in development of high-quality clinical guidance products consistent with broadly-accepted, evidence-based principles and processes appropriate to the needs of the epilepsy clinical community. Recognizing that process adaptations will be discovered through experience, causing process specifics to evolve, this manual is provided as a living document and will be updated accordingly.

AES Clinical Guidance in Development

More information and protocols for public comment will be posted here for the following projects currently in the early stages of development:

  • AES/ACNS Electrocorticography (ECoG) Systematic Review and Guideline
  • AES/AAN/CNS Epilepsy Surgery Systematic Review and Guideline


Resources pertaining to comorbidities of epilepsy are listed by Guidelines or Practice Parameters. All practice parameters and guidelines related to the care and treatment of epilepsy are developed collaboratively between the American Epilepsy Society and the American Academy of Neurology. Members of the AES sit on all epilepsy-related guideline workgroups. 

Evidence-based Guidelines

Practice Parameters

Additional Papers

The American Epilepsy Society offers the following definition of Guidelines listed in this section. 

Guidelines – evidence based. Examples are the guidelines developed through the AAN mechanism with input and inclusion from AES members. Each guideline makes specific practice recommendations based upon a rigorous and comprehensive evaluation of all available scientific data. ILAE is another common resource. Others organizations will be considered such as American Academy of Pediatrics, and nursing organizations.

Approval process: Approval is through individual societies, but then scored by the AES Guidelines Committee.

Disclaimer: These guidelines are designed to assist clinicians by providing an analytic framework for evaluating and treating patients. It is not intended to establish a community standard of care, replace a clinician’s medical judgment, or establish a protocol for all patients. The clinical conditions contemplated by these guidelines will not fit or work with all patients. Approaches not covered in these guidelines may be appropriate.

Reviewed:  Guidelines Committee, 2015