Annual Meeting Abstracts: View
(Abst. 2.196), 2015
Epilepsy and Reproductive Issues in Women of Hispanic Origin Living in United States
Authors: Olgica Laban-Grant, Martin Lancman, Corazon B. de la Pena, Munazza Malik, Sloka S. Iyengar, Evan Fertig, Pavel Klein, Marcelo Lancman
Content: Rationale: Previous studies suggested that women’s health issues depend on ethnic background amongst other factors. Adequate treatment of women with epilepsy may require understanding of the broader socio-economic context including ethnic background. The aim of this study is to evaluate self-reported issues in community-based women with epilepsy of Hispanic origin living in U.S. compared to women of other ethnic backgrounds.Methods: Comprehensive questionnaire of women- related health issues was systematically administered to women with epilepsy aged 12 years and older in one large private epilepsy practice. The questionnaire consisted of 31 questions addressing seizure and menstruation, pregnancy, menopause and contraception, and reproductive outcomes in women with epilepsy. Information about epilepsy was obtained from medical records. This data was compared to data collected from women not of Hispanic origin.Results: Thirty-two women of Hispanic origin completed the questionnaire, twenty two with partial epilepsy and ten with generalized epilepsy. One hundred and twenty four women not of Hispanic origin completed the questionnaire, 91 with partial epilepsy and 33 with generalized epilepsy. Association of seizures with menstrual period was similar between the Hispanic and non-Hispanic group (34% vs. 30%, NS). There was no significant difference in onset of menarche or menopause between two groups. There was a trend in reporting earlier onset of menopause in women of Hispanic origin (41.6 years vs. 46.5 years, t=-1.88; P-Value = 0.07). Equal number of women in each group reported change in seizure frequency after menopause (33%). No Hispanic women reported fertility problems; 6/124 women in non-Hispanic group reported treatment for fertility (NS). Women with epilepsy of Hispanic origin were less frequently aware of possible interactions between antiseizure medications and hormonal contraception (9% vs 52%, Fisher exact test, p<0.05).Conclusions: Hispanic women with epilepsy were significantly less aware of possible interactions between hormones and antiseizure medications. This underscores the importance of systematic survey of different populations in identifying areas for further education effort in women with epilepsy. Trend for earlier onset of menopause in women with epilepsy of Hispanic origin suggests possible difference in the impact of epilepsy on reproductive health depending on ethnic background.