Basic Science Toolkit

The information below is organized by major topics and sub-topics in basic epilepsy research.  Each section includes a contact link to investigators who can be contacted for help with common methods in basic epilepsy research and links to additional resources and references about the methods.

This page is intended as a living resource. If you have suggestions for additional key reference resources or are interested in serving as a contact resource, please contact Helen Scharfman.

Models of Seizures and Seizure Testing in Laboratory Animals

Animal Models of Epilepsy Induced by Insult or Injury

Status epilepticus

Kindling

Traumatic brain injury

Tetanus Toxin

Febrile seizures

Neonatal hypoxia

    • Frances Jensen
      • Sanchez RM, Jensen FE (2005) Modeling hypoxia-Induced seizures and hypoxic encephalopathy in the neonatal period. In: Models of Seizures and Epilepsy. A Pitkanen, PA Schwartzkroin, SL Moshe, Eds. Elsevier, New York.
    • Shilpa Kadam 

Infantile spasms

Cortical dysplasia, tuberous sclerosis

Epilepsy induced by infection, inflammation or blood brain barrier /vascular manipulations

Other Models of Epilepsy

Genetic mouse models of epilepsy

Hormone-sensitive epilepsy, sex differences

Absence epilepsy

    • GAERS
      • Antoine DePaulis
        • DePaulis A, Van Luijtelaar G (2006) Genetic models of absence epilepsy in the rat. In: Models of Seizures and Epilepsy. Pitkanen A, Schwartzkroin PA, Moshe SL Eds.
      • Terrence O’Brien 
    • WAG/Rij
      • Gilles Van Luijetlaar
        • Van Luijtelaar G, Coenen A (2009) Genetic models of absence epilepsy: new concepts and insights. In: Encyclopedia of Basic Epilepsy Research. Schwartzkroin PA (Ed.) Oxford: Elsevier.
      • Terrence O’Brien

Zebrafish

Other Methods in Epilepsy Research

Video-EEG recording of seizures in epileptic rodents (rats)   

Analysis of EEG

Optogenetics in epileptic rats and mice

Molecular or genetic analyses

Epigenetics in epileptic aninals

Behavior in epileptic animals

Imaging of epileptic rats and mice in vivo

Imaging of epileptic tissue. in vitro (primarily)

Neuropathology in epileptic animals

 

This is a work in progress. If you have suggestions or would like to be listed contact Helen Scharfman (hscharfman@nki.rfmh.org)

Disclaimer: AES is providing this document for information only, and it is not intended to suggest a particular approach to research. Determination of whether and/or how to use all or any portion of this document is to be made in your sole and absolute discretion. No part of this document constitutes advice.