Abstracts

Rationale: Status Epilepticus (SE) is a neurological emergency and predicting outcome remains a challenge based only on clinical and electroencephalography findings. Actually, two validated clinical scoring systems as Status Epilepticus Severity Score (STESS) and Epidemiology-based Mortality score in Status Epilepticus (EMSE) are used to predict mortality. Albumin and white blood cells (WBC) have been postulated as pro-inflammatory markers of the outcome in SE. The aim of this study was to determine the associations between serum albumin level and WBC with outcome of SE. Methods: A retrospective study of 45 consecutive patients with SE admitted at Hospital Britᮩco de Buenos Aires from 2009-2015. Evaluation of level of consciousness, age, worst seizure type, history of previous seizures, comorbidity, etiology and EEG were determinate to perform STESS and EMSE scores. Serum albumin levels and WBC were assessed at SE onset and 1 day after SE onset. To analyze data, we used GraphPad-prism 5 software and STATA-12 software. Relationship between survival and non-survival patients was calculated by Mann-Whitney test, and categorical variables were compared using Fisher test. P < 0.05 was used as significant. Results: In our group of patients (31 females) the average age was 70.4 SEM ± 2.2 years old (range 16-91). Of the 45 patients included in the analysis 12 died. Patients had a mean WBC of 9580 SEM± 761.01 (range 100-23100), mean serum albumin level at SE onset of 3.12 SEM ±0.07 (range 2.0-4.1) and mean serum albumin level of 2.86 SEM± 0.07 (range 1.8-3.9). We didn’t find a correlation between serum albumin level and WBC with STESS score (p= 0.10; p=0.93; p= 0.85 respectively). Nevertheless, we found a statistically significant correlation between EMSE-EACE and EMSE-EAC scores with serum albumin level at SE onset (p= 0.035; p= 0.031 respectively) and 1 day after SE onset (p=0.037; p=o.o32 respectively). Conclusions: We found a relationship between low serum albumin level and high EMSE score. Based on these findings we propose that serum albumin level could be a biological marker of SE outcome. Funding: No