Abstracts

Rationale: Epilepsy is one of the most common diseases of the nervous system. It is known that the basis of the disease is increased epileptiform activity, due to the peculiarities of the course of the brain's metabolic processes. A certain role is played  by endocrine disorders and metabolic disorders, in particular lipid.The purpose of this study is to to investigate the changes in lipid metabolism in men with epilepsy in the postseizure period and against the background of taking antiepileptic drugs (AEDs). Methods: The studies were conducted on the basis of the analysis of clinical symptoms and instrumental studies (biochemical blood analysis - lipid spectrum, determination of the level of AEDs concentration in the blood). EEG, EEG-video monitoring, MRI, Proton MR Spectroscopy (definition of Lip, Lac) were used as the screening methods. Results: The analysis of the data of 50 patients aged  from 20 to 50. After the survey 25 people in the postseizure period had a Lac peak and 5 people had a Lip peak, which occurs when lipid peroxidation processes are disrupted. Such disorders of lipid metabolism may be one of the factors of neuronal membrane damage.     Changes in lipid metabolism are associated with some AEDs and may cause long-term adverse health effects. These changes were observed in 15 patients. Carbamazepine (CBZ), phenobarbital (PB) and phenytoin (PHT) increase high-density lipoproteins (HDLs), CBZ has cholesterol-lowering effects, PB and PHT may exert a similar cholesterol-lowering effect. Counteracting these favorable lipid trends, elevations in low-density lipoproteins (LDLs) are reported with CBZ and PB, and VPA increases LDLs as well as HDLs, leading to an unfavorable lipid profile.       The patients accepting carbamazepine, had a rise in concentration of medicine up to 14 µg/ml. At reception of a phenytoin at 7 persons rise in concentration to 18 µg/ml was noted, while receiving valproate up to 80 µg/ml. While receiving phenobarbital rise in the concentration was observed up to 25 µg/ml. Conclusions: All patients showed multidirectional changes in lipid metabolism, which require further study. Disorders of lipid metabolism largely depend on the intake and daily dosage of AEDs. Funding: None