CLINICAL COMPARISON BETWEEN PATIENTS WITH PERIVENTRICULAR NODULAR AND SUBCORTICAL HETEROTOPIAS
Abstract number :
2.018
Submission category :
Year :
2003
Submission ID :
1071
Source :
www.aesnet.org
Presentation date :
12/6/2003 12:00:00 AM
Published date :
Dec 1, 2003, 06:00 AM
Authors :
Damian E. Consalvo, Agustin Alurralde, Estela Centurion, Walter H. Silva, Pablo A. Salgado, Patricia Saidon, Silvia S. Kochen, Roberto E. Sica Epilepsy Center, Ramos Mejia Hospital, Buenos Aires, Argentina; FEMIEN Foundation, Buenos Aires, Argentina; CONI
Developmental malformations are a group of entities that are produced during the embryogenesis. One type of these abnormalities are the neuronal migration disorders, and between them, we can include the heterotopias (HT).
The aim of the syudy was to compare patients with periventricular nodular HT (G1) and patients with subcortical HT, with extension to the lateral walls of the subjacent ventricle (G2).
The variables analyzed were sex, age, age of onset of their epilepsy (AO) in years, antecedents, monthly seizure frequency (MSF), semiological characteristics of the seizures, EEG and MRI findings and response to the treatment.
G1 (n=13): 8 women (58.3%), average age 32.9 [plusmn] 11.6 (range 20-59), AO 13.7 [plusmn] 7.6 (range 2-23), MSF 2.3 [plusmn] 2.6 (range 0-10), multifocal seizures in 5 (38.4%), temporal lobe seizures in 9 (69.2%), epileptiform abnormalities on the EEG (EAEEG) in 7 cases (58.3%), coincident with the symptomatogenic zone (SZ) in 6 (85.7%), abnormalities associated on the MRI (AAMRI) in 8 (61.5%) and refractory to the treatment (RT) in 4 (30.7%). G2 (n=8): 6 women (75%), average age 30 [plusmn] 9.7 (range 13-43), AO 11.1 [plusmn] 6.3 (range 1-19), MSF 2.5 [plusmn] 3.2 (range 0-10), multifocal seizures in 4 (50%), temporal lobe seizures in 5 (62.5%), EAEEG in 7 cases (87.5%), coincident with the SZ in all of them (100%), AAMRI in 3 cases (37.5%) y RT in 1 (12.5%).
Epilepsy patients with heterotopic lesions instead of dissimilar findings on the MRI studies do not have differences in their clinical or electrophysiological presentations.
[Supported by: Ministerio de Salud de la Naci[oacute]n]