Abstracts

Rationale: EEG monitoring is the ultimate way to diagnose status epilepticus in clinical practice. However it needs interpretation of experts in prompt managing seizures. Amplitude-integrated EEG (aEEG) is a digital trend analysis to monitor cerebral background activity continuously via processed interested channel EEG. In this study, our aim is to find out clinical utility  and  validity of amplitude-integrated EEG (aEEG) for non-EEG experts. for identification of electrographic seizure in patients with status epilepticus Methods: We retrospectively reviewed continuous EEG recordings of 28 patients diagnosed as status epilepticus who showed clinical or electrographic seizures during monitoring in Korea University Anam Medical Center from 2014 to April, 2016We excluded subjects showed continuous static ictal discharges during monitoring.Electrographic seizure was defined as repetitive or rhythmic generalized or focal epileptiform discharges, or rhythmic waveforms with freque11ncy 3-20 Hz lasting more than 10 seconds under agreement of two EEG experts.We converted EEG into aEEG displays by three electrodes  on each side (frontal, central and parietal; F7/8, C3/4,P7/P8), and tried to characterize four aEEG patterns presenting EEG seizuresAfter training the pattern recognition, three medical students visually analyzed the aEEG of 8 subjects without EEG and marked time points of start/end.Their results were compared with notated time points of electrographic seizure by two epileptogists and assessed concordance of time interval in terms of 10 second-epoch within ±10 seconds Results: The mean age was 72.5 ± 5.2  years old and there are six males among 8 sugjects. Total recoreding epoch is 37,701 and there were 680 electrographic seizures. The sensitivity for detecting electrographic seizure tby means of aEEG was in range of 0.74-0.78 ane the specificity was 0.60. (kappa 0.41 - 0.28)  Conclusions: Amplitude-integrated EEG patterns showed respectively high sensitivity assuming electrographic seizures in non-EEG experts.The utility of aEEG for recognizing electrographic seizures by non-expertise surveillants keeping near the patients can help prompt seizure control even during night and  improve outcome of patients with status epilepticus. Funding: None