Abstracts

Rationale: Impulsivity is the inability to confirm behavior to its context or consequences. Our group previously demonstrated the presence of higher expression of novelty seeking behavior in patients with Juvenile Myoclonic Epilepsy (JME) (Moschetta et al. 2011), as well as its impact in social functioning (Moschetta & Valente 2013). Functional and microestrutural abnormalities in frontal lobes have been demonstrated in these patients and may explain this behavior. However, frontal lobe dysfunction is also seen in patients with TLE (Rzezak et al. 2007). In this context, this study aimed to: (1) evaluate impulsiveness in patients with JME considering non-planning, cognitive-attentional and motor domains; (2) compare JME with temporal lobe epilepsy caused by hippocampal sclerosis (TLE-HS) and healthy controls. Methods: We evaluated 19 patients with JME (mean age 31.83; 12 male); 20 patients with TLE-HS (mean age 37.53; 5 male) and 20 healthy controls without epilepsy and psychiatric disorders (mean age 32.58; 6 male). Patients were assessed using the Barrat Impulsiveness Scale (BIS). Beck Depression Inventory (BDI) and STATI- Trait and State were also applied. Statistical analysis was performed using oneway ANOVA comparing the three groups and a post-hoc analysis of Scheffe. Results: There was no difference for age (p 0.199). The total score of impulsiveness according to BIS in JME was 78.26 (SD 9.54); 39.50 (SD 14.00) in TLE-HS and 47.10 (SD 18.59) in healthy volunteers (p 0.000). The analysis of each subdomain in JME; TLE-HS and healthy controls is represented in Tales 1 and 2. Conclusions: Based on our findings, patients with JME described more planning, motor control and cognitive-attentional behavior problems than patients with TLE-HS and healthy volunteers. It is of note that there were no differences comparing patients with TLE-HS and healthy volunteers in any of the BIS subdomains. Over impulsiveness poses as a major clinical dilemma that must be diagnosed and treated in patients with JME. References Moscheta SP, et al. Epilepsy Behav. 2011 Aug;21(4):473-7. Moschetta SP; Valente KD. Epilepsia. 2013 May;54(5):866-70. Rzezak P, et al. Frontal lobe dysfunction in children with temporal lobe epilepsy. Pediatr Neurol. 2007 Sep;37(3):176-85.