Epileptiform activity detected from simultaneous MEG and EEG in patients with Alzheimer’s disease
Abstract number :
483
Submission category :
3. Neurophysiology / 3D. MEG
Year :
2020
Submission ID :
2422825
Source :
www.aesnet.org
Presentation date :
12/6/2020 5:16:48 PM
Published date :
Nov 21, 2020, 02:24 AM
Authors :
Manuela Ochoa-Urrea, University of Texas in Houston-McGovern Medical School; Michael Funke - University of Texas in Houston-McGovern Medical School; Fernando Maestu - University of Texas in Houston-McGovern Medical School; John Mosher - University of Texa
Rationale:
Interrelations between Epilepsy and Alzheimer’s disease (AD) are relatively understudied. AD patients are more likely to display epileptiform activity and seizures than a normal age-matched population and other non-AD dementias. Epileptiform activity and ictal EEG abnormalities are evidence of underlying hyperexcitability and have been linked to cognitive impairment in animal models and humans with AD. However, this neurophysiological phenomenon has been rarely evaluated in preclinical or early stages of the disease using Electroencephalography (EEG) and Magnetoencephalography (MEG), simultaneously.
Method:
We report a preliminary series of five consecutive patients on the AD spectrum with no history of seizures, in whom we recorded EEG and MEG using 64 EEG electrodes, including the subtemporal array, and 306 MEG sensors during resting state for 120 minutes. An expert in either EEG or MEG visually inspected for epileptiform activity. After spike detection, a source reconstruction model, using individual MRIs and single dipole approach, was computed to test the brain sources for the spike-related primary electrical currents.
Results:
One patient with presymptomatic AD, two with mild cognitive impairment amnestic type due to prodromal AD and two with mild probable AD dementia participated. Three displayed potential epileptiform activity. Spikes were located in the left mesial temporal lobe in one subject, right fronto-opercular in another and bitemporal in a third subject. This epileptiform activity was found more often in MEG, and in two patients it had a clear low voltage EEG correlate.
Conclusion:
Patients in the early stages of AD display epileptiform activity, better visualized in MEG. Clinical follow-up and correlation with biomarkers are needed to fully understand the clinical meaning of this epileptogenic activity. Detecting these epileptogenic features early in AD could prompt changes in clinical decisions and treatment and potentially slow cognitive decline.
Funding:
:No funding was received in support of this abstract
Neurophysiology