Epileptiform and Sleep Spindle Activity in Anterior Nucleus of the Thalamus in Temporal Lobe Epilepsy Patients
Abstract number :
3.039
Submission category :
1. Basic Mechanisms / 1C. Electrophysiology/High frequency oscillations
Year :
2018
Submission ID :
502828
Source :
www.aesnet.org
Presentation date :
12/3/2018 1:55:12 PM
Published date :
Nov 5, 2018, 18:00 PM
Authors :
Daniel Fabo, National Institute of Clinical Neurosciences; Zsofia Jordan, National Institute of Clinical Neurosciences; Boglarka Hajnal, National Institute of Clinical Neurosciences; Robert Bodizs, Semmelweis University; Laszlo Halasz, National Institute
Rationale: Anterior nucleus of the thalamus (ANT) is a new target site for DBS treatment in epilepsy. The role of the ANT in the epileptic networks, and the potential role of local field potential (LFP) recording for patient selection is entirely unknown. We recorded LFP from ANT in temporal lobe epilepsy patients. Methods: In this present study we included 12 ANT-DBS bitemporal epilepsy patients with externalized leads and surface electrodes undergoing 2 days video-EEG monitoring (VEM). We investigated IIDs, ictal events (IE) and SSs in ANT and also in surface EEG recordings. IIDs and IEs were analysed by visual inspection, SSs were detected according to the patient own special spindle frequency, separately on the scalp (Fp1-2, F3-4, F7-8) and thalamus both sides. SS spectral peak frequency and synchronization between scalp and ANT was measured. Results: IIDs appeared in the thalamus and on the scalp both in a dependent and independent manner. Three patients had seizures during VEM. Seizures did not start but spread to the ANT electrodes in all cases. The slow, frontal type of SSs were prevailing in the ANT. Conclusions: ANT participates in both sleep and epileptogenic processes. It seems that IIDs and IE spread to the ANT. Frontal, slow frequency SSs has local sources in the ANT indicating its participation in sleep processes. Further evaluation for seizure outcome of ANT-DBS therapy and correlation with ANT recordings are underway. Funding: NKFIH 2017-1.2.1-NKP-2017-00002; NIH 2R56NS062092