Abstracts

To report findings on temporal lobe epilepsy (TLE) due to mesial temporal sclerosis (MTS) population at UNIPETE, from 2000 to 2005, including epidemiologic, imaging and natural history data. All diagnosed TLE due to MTS outpatients were included. Epidemiologic data was performed, as well as age and kind of initial precipitating insult (IPI) if present, age at first and second seizures, time spared until maximal tolerated dosage (MTD) of antiepileptic drugs (AEDs), presence of remission period, epileptogenic zone lateralization, age at MTD and age at surgery if applicable were evaluated. We had 149 patients, aged 16 to 72 (40[underline]+[/underline] 10years), 81 (54.36%) female, (85.23%) right-handed. According to lesion area, 80 (53.69%) were left-sided, 59 (39.59%) were right-sided and 10 (6.7%) were bilateral. 63 (42.28%) had IPI, mainly febrile seizures (52%). First spontaneous seizure (FSS) occurred from 0,08 to 55 years (11[underline]+[/underline]10). Remission of seizures was seen in 31(21%). 89 (60%) reached MTD at 39[underline]+[/underline]9, 28[underline]+[/underline]11.5 years after FSS. 52 surgeries has been performed, age at surgery was 39[underline]+[/underline]9, 29[underline]+[/underline]12 years after diagnosis. TLE due to MTS in this service seem to present similar points to what previously described in literature; the time spared from first seizure to MTD is larger than that observed in developed countries, which might be related to socio-economic conditions, leading to surgeries later in life, with all its related consequences. (Supported by FAPESP.)