Super Refractory Status Epilepticus treated with Anakinra in Febrile Infection Related Epilepsy Syndrome
Abstract number :
2.440
Submission category :
4. Clinical Epilepsy / 4C. Clinical Treatments
Year :
2017
Submission ID :
403367
Source :
www.aesnet.org
Presentation date :
12/3/2017 3:07:12 PM
Published date :
Nov 20, 2017, 11:02 AM
Authors :
Alejandra Genel, Hospital Infantil de Mexico Federico Gomez; Alejandra Castañon, Instituto Mexicano del Seguro Social Centro Medico Nacional Siglo XXI; Andrew White, Denver Health; and Krista Eschbach, Children's Hospital Colorado, University of Colorado
Rationale: Febrile Infection Related Epilepsy Syndrome (FIRES) is an epileptic encephalopathy in response to infection and or fever in a previous normal child. Anakinra is an interleukin- 1 receptor antagonist and is now approved for its use in patients with FIRES. The objective for this poster is to present the evolution of FIRES and treatment with Anakinra. Methods: CLINICAL CASE. A 11-year-old boy, previously healthy; after a tick bite presented with fever, altered mental status and super refractory status epilepticus with focal left temporal discharges and later on, ipsilateral hemispheric PLEDs. Results: After multiple AED and unfavorable response, he was started with immunosuppressive treatment with Anakinra with a favorable outcome. Conclusions: FIRES is an immune mediated encephalopathy with unknown etiology therefore it is a difficult entity to treat initially and it is a diagnosis of exclusion. In this specific case the response to Anakinra was surprising, this helps us to support one of the hypothesis for its probable underlying mechanisms, and to remember to have levels of IL-1 in CSF at the beginning and ending of treatment. Funding: No funding was received in support of this abstract
Clinical Epilepsy