THE ADDED VALUE OF MAGNETIC SOURCE IMAGING IN A LARGE SERIES OF MEDICALLY REFRACTORY PARTIAL EPILEPSY PATIENTS THAT ARE CANDIDATES FOR EPILEPSY SURGERY
Abstract number :
2.219
Submission category :
Year :
2003
Submission ID :
3826
Source :
www.aesnet.org
Presentation date :
12/6/2003 12:00:00 AM
Published date :
Dec 1, 2003, 06:00 AM
Authors :
Fatima N. Janjua, Dawn S. Eliashiv, Itzhak Fried Division of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA; Neurology, University of California, Los Angeles School of Medicine, Los Angeles, CA
Magnetic source imaging (MSI)/magnetoencephalogram (MEG) is a noninvasive localizing tool that has been recently increasingly used in the evaluation of patients with partial epilepsy patients that are considered to be candidates for resective epilepsy surgery. Patients that are insufficiently localized may need to be subjected to more invasive recordings with depth or subdural electrodes which are associated with increased morbidity and mortality.
Between 1996 and 2002, 100 patients underwent MSI/MEG. 18 patients had resective surgery with invasive electrode testing., which was also based on MEG localization. MEG was performed utilizing either dual dewar or whole head MEG system at Scripps Clinic, San Diego, CA. Interictal localizations were computed based on single equivalent current dipole (ECD) with a goodness of [gt]0.98 that were subsequently superimposed on patients MRI of the brain.
9 patients were completely seizure free following surgery (follow up times varied from one month to two years), 3 had greatly decreased seizure frequency and the remaining, 2 continued to have seizures of unchanged frequency and the remaining 4 were lost to follow up.
MSI/MEG is an excellent noninvasive localizing tool in patients that are candidates for epilepsy surgery that can spare the need for further invasive monitoring. The majority of patients, have excellent surgical outcomes.