THE RISK FACTORS OF STATUS EPILEPTICUS IN CHINESE CHILDREN
Abstract number :
1.167
Submission category :
Year :
2003
Submission ID :
2067
Source :
www.aesnet.org
Presentation date :
12/6/2003 12:00:00 AM
Published date :
Dec 1, 2003, 06:00 AM
Authors :
Yi Wang, Daokai Sun, Jin Zhang, Yiyun Shi, Hui Xu Neurology Department, Children[apos]s Hospital of Fudan University, Shanghai, China
Status epilepticus (SE) is one of the most important neurological emergencies. Between 15% to 27% of patients with epilepsy will experience at least 1 episode of status epilepticus. The goal of this study is to identify the risk factors associated with SE in the population of epileptic children in China.
We designed a case-control study for patients with SE attending in neurology clinic of Children[rsquo]s Hospital of Fudan University in Shanghai from January 2000 to December 2002. SE was defined as a clinical seizure lasting 30 minutes or longer, or repeated seizures without recovery. Patients who presented at least one status epilepticus were enrolled in the study. Control subjects were selected, matched for age and sex, from a group of non-SE patients with epilepsy in the same hospital and during the same period. Information on etiology, family history, febrile convulsion history, age of onset, seizure types, EEG findings, CT/MRI data, intellectual disability, initiation of treatment, anticonvulsants administered, number of episodes of SE were ascertained from personal interview and review of the medical records and were analyzed with conditional Logistic regression analysis.
77 patients with SE and 154 control patients with epilepsy but non- SE were enrolled in this study. The mean age was 5.1[plusmn]3.8 years old. Twenty-four variables were analyzed. On univariate analysis, a significant positive association was found with certain etiology, seizure as SE before, retractable seizure, complex partial or partial secondary to the generalized seizure, abnormal neurological image, abnormal background or focal spike in EEG and poor-compliance with antiepileptic drugs. On multiple factor analysis, symptomatic epilepsy(OR=5.62; 95%CI: 3.68~8.14); seizure as SE before(OR=4.50; 95%CI: 3.46~5.26); complex partial seizure(OR=2.96; 95%CI: 2.13~4.20); partial secondary to the generalized seizure(OR=2.40; 95%CI: 2.16~2.89); abnormal EEG background(OR=2.06; 95%CI: 1.08~4.10); poor- compliance with antiepileptic drugs medication(OR=1.72; 95%CI: 1.05~2.33)were found to be risk factors for SE.
Our study suggests that these six factors increase a subject[apos]s risk of developing SE as compared to age- and sex-matched controls.
[Supported by: Children[apos]s Hospital of Fudan University]