Use of the Yale Brain Atlas to Compare Signatures of Cortical Thinning Based on Seizure Onset Location
Abstract number :
3.233
Submission category :
5. Neuro Imaging / 5A. Structural Imaging
Year :
2023
Submission ID :
1121
Source :
www.aesnet.org
Presentation date :
12/4/2023 12:00:00 AM
Published date :
Authors :
Presenting Author: Alexander King, BS – University of California, Berkeley
Sami Obaid, MD – Universite de Montreal; Kelly Pu, BS – Yale University School of Medicine; Omar Chishti, BS – Yale University School of Medicine; Evan Collins, BS – Massachusetts Institute of Technology; David King-Stephens, MD – Yale University School of Medicine; Dennis Spencer, MD – Yale University School of Medicine; Hitten Zaveri, PhD – Yale University School of Medicine
Rationale:
Cortical thinning is a natural process that occurs with age. This phenomenon is often accelerated in patients that have epilepsy. Global cortical thinning has been reported in patients with frontal and temporal lobe onset seizures compared to normal controls. This study looks at how global cortical thinning relates to lobar seizure onsets. We employed the Yale Brain Atlas (YBA), a finely neuroanatomically defined brain atlas composed of 690 parcels.
Methods:
Forty-one drug resistant, non-lesional patients from the Yale Comprehensive Epilepsy Center and 136 control subjects from the Human Connectome Project were included in the analysis. Seizure localization was determined by invasive EEG in 12 patients with frontal lobe, three with parietal lobe, and 26 with temporal lobe seizure foci. Patients with bilateral seizure onsets and multi-lobar onsets were excluded. Cortical thickness maps were calculated using non-skullstripped T1 weighted MR scans and coregistered to the MNI152 brain using Advanced Normalization Tools (ANTs). The Yale Brain Atlas was then used to extract cortical thickness values from subregions and further organized into lobes and parcels.
Results:
In normal subjects, cortical thickness varies across the cortex with the thinnest cortex being seen in the parietal lobe and the thickest cortex being seen in the temporal lobe. Variable loss of cortical thickness was seen across the brain in patients with epilepsy. Between groups, those with parietal lobe onsets demonstrated the greatest degree of global thinning followed by temporal and frontal lobe onsets. Cortical thickness was lower in parietal lobe patients in comparison to temporal lobe patients (p < 0.001, t-test) and cortical thickness was lower in temporal lobe patients in comparison to frontal lobe patients (p < 0.001).
Neuro Imaging