WHITE MATTER ABNORMALITIES IN SCLEROSIS TUBEROUS COMPLEX: A UNDERDIAGNOISED [quot]MINOR[quot] CRITERIA?
Abstract number :
1.073
Submission category :
Year :
2005
Submission ID :
5125
Source :
www.aesnet.org
Presentation date :
12/3/2005 12:00:00 AM
Published date :
Dec 2, 2005, 06:00 AM
Authors :
Rosanna Chifari, Ada Piazzini, Lionello Caverni, Alberto Formenti, Elena Lesma, Katherine Turner, Alfredo Gorio, Raffaele Canger, and Maria Paola Canevini
Neuroimaging studies of tuberous sclerosis complex (TSC) have previously focused mainly on tubers or subependymal nodules. Subtle pathological changes as white matter abnormalities in the structure of the brain have not been focused .
We utilized MRI techniques for reliable study of brain structure to reach an accurate computation of brain abnormalities in patients with TSC . Dual-echo, FLAIR and IR MRI data were acquired from 28 TSC patients with a cognitive level ranging from mild to severe.
Differences in gray matter, white matter abnormalities were estimated at each intracerebral voxel FLAIR images were acquired for neuroradiological rating of tuber number. We also found significant alteration of white matter as stripes and candle guttering excrescences of groups of atypical cells perpendicular to the ventricular wall 21 of 28 TSC affected patients involving major intrahemispheric tracts and a bilateral cerebellar region .Furthermore the white matter abnormalities are note related to the tubers. Neuropathological changes of white matter associated with TSC may be more extensive than prior suspected and it could be a underdiagnoised [ldquo]minor[rdquo] criteria