The American Epilepsy Society is a trusted source of evidence-based clinical guidance for epilepsy specialists and other healthcare providers. 


New Guideline: Epilepsy and Pregnancy

A new practice guideline on epilepsy and pregnancy is available from the American Academy of Neurology (AAN) in collaboration with AES and the Society for Maternal-Fetal Medicine (SMFM). The guideline, Teratogenesis, perinatal, and neurodevelopmental outcomes after in utero exposure to antiseizure medication: Practice guideline from the AAN, AES, and SMFM, was published May 15, 2024, in Neurology® online, with upcoming co-publication in Epilepsy Currents to follow.

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Additional tools and resources are available on

    AES Clinical Guidance in Development

    • AES Management of Infantile Epilepsies Systematic Review Update and Guideline
    • AES/ACNS Intraoperative Electrocorticography (ECoG) Systematic Review and Guideline
    • AES/CNS Epilepsy Surgery Systematic Review and Guideline
    • AES/NCS Status Epilepticus Systematic Review and Guideline


    Evidence-Based Guidelines



    2020 AES CPG Development Manual

    AES Clinical Practice Guideline Development Manual (2020)
    This manual outlines principles and processes intended to guide AES-led workgroups in the development of high-quality clinical guidance products consistent with broadly accepted, evidence-based principles and processes appropriate to the needs of the epilepsy clinical community.